Thornton Ross Codeine Phosphate Oral 25mg/5ml Solution 500ml is used for Relief of mild to Buy Thornton Ross Codeine moderately severe pain and
other conditions. The Codeine Phosphate Oral Solution may also be use for purposes not listed in this medication guide.
Firstly, this Oral Solution is use for the treatment, control, prevention, & improvement of the following diseases. Conditions and symptoms: Relief of
mild to moderately severe pain This Phosphate Oral Solution may also be use for purposes not listed here.
Codeine is metabolized by the liver enzyme CYP2D6 into morphine, its active metabolite. If a patient has a deficiency or is completely lacking this
enzyme an adequate analgesic effect will not be obtain. Estimates indicate that up to 7% of the Caucasian population may have this deficiency. However,
if the patient is an extensive or ultra-rapid metabolizer there is an increased risk of developing side effects of opioid toxicity even at commonly
prescribed doses. These patients convert codeine into morphine rapidly resulting in higher than expected serum morphine levels.
General symptoms of opioid toxicity include confusion, somnolence, shallow breathing, small pupils, nausea, vomiting, constipation and lack of appetite.
In severe cases this may include symptoms of circulatory and respiratory depression, which may be life-threatening and very rarely fatal. Estimates of
prevalence of ultra-rapid metabolizer in different populations are summarize.
Lastly, the product should not be use during pregnancy unless consider necessary by the physician. Also and should be avoid in the first trimester. Also
opioid administration in the third trimester may cause respiratory depression in the new born. However withdrawal effects in neonates of dependent
mothers, gastric stasis and risk of inhalation pneumonia in the mother during labour.
Furthermore, the recommended codeine dose for children 12 years and older should be one or two 5ml spoonfuls (25-50mg codeine). In addition,every ctivate Winde
6 hours when necessary up to a maximum dose of codeine of 240 mg daily. The dose is based on the body weight (0.5-1mg/kg).